5-oxo-15-HETE: total synthesis and bioactivity

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1857-60. doi: 10.1016/j.bmcl.2011.01.032. Epub 2011 Jan 25.

Abstract

The first total synthesis of 6(E),8(Z),11(Z),13(E) 5-oxo-15-HETE 4 was accomplished. The synthetic material was evaluated with calcium mobilization assay and compared with 5-oxo-ETE the natural ligand for the OXE receptor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Humans
  • Hydroxyeicosatetraenoic Acids / chemical synthesis*
  • Hydroxyeicosatetraenoic Acids / pharmacology*
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Neutrophils / drug effects
  • Receptors, Eicosanoid / drug effects

Substances

  • Hydroxyeicosatetraenoic Acids
  • Ligands
  • OXER1 protein, human
  • Receptors, Eicosanoid
  • 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid