Abstract
The first total synthesis of 6(E),8(Z),11(Z),13(E) 5-oxo-15-HETE 4 was accomplished. The synthetic material was evaluated with calcium mobilization assay and compared with 5-oxo-ETE the natural ligand for the OXE receptor.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Humans
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Hydroxyeicosatetraenoic Acids / chemical synthesis*
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Hydroxyeicosatetraenoic Acids / pharmacology*
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Ligands
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Magnetic Resonance Spectroscopy
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Neutrophils / drug effects
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Receptors, Eicosanoid / drug effects
Substances
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Hydroxyeicosatetraenoic Acids
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Ligands
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OXER1 protein, human
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Receptors, Eicosanoid
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5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid